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Details of Grant 

EPSRC Reference: EP/D03213X/1
Title: A CYCLOADDITION STRATEGY FOR ARYLPHOSPHINE SYNTHESIS
Principal Investigator: Harrity, Professor JPA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of Sheffield
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 2006 Ends: 31 March 2010 Value (£): 100,082
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
Small quantites of metal catalysts can greatly affect the chemistry of simple organic molecules, leading to more efficient and cost effective processes. The metallic agent is very often added to a reaction as a complex, meaning that the metal centre is surrounded by other organic molecules known as ligands. The ligands help solubilise the metal species but they also play an important role in fine tuning the chemistry that takes place at the metal centre. This project aims to develop a very quick method for making a wide range of ligands that are based around a phosphorus centre. Indeed, phosphine based ligands are amongst the most popular and important in metal catalysed reactions. If successful, this project will deliver new ligands that have the potential to greatly improve the efficiency and selectivity of many reactions, allowing a diverse range of fine chemicals to be made available by cheap and simple processes.
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Organisation Website: http://www.shef.ac.uk