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Details of Grant 

EPSRC Reference: EP/D002818/1
Title: Asymmetric approaches to 3-hydroxy and 3-aminooxindoles: the first synthesis of (N-indolo)pyrroloindole alkaloids
Principal Investigator: Marsden, Professor SP
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Leeds
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 2005 Ends: 30 September 2008 Value (£): 99,262
EPSRC Research Topic Classifications:
Asymmetric Chemistry Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
3-Hydroxy and 3-aminooxindoles form substructures of a large number of pharmaceutical candidates and naturally-occurring biologically compounds. The presence of the 3-hydroxy or 3-amino functionality in these molecules means that they can potentially exist as one of two forms, identical to each other except that they are mirror images. In nature, they nearly always occur as a single one of these mirror image forms. As chemists, it is much simpler to prepare compounds as an equal mixture of the two mirror-image forms, and the pharmaceutical candidates reported to date have indeed been prepared in this way. However, for new drugs to be licensed they must be prepared as single mirror-image forms: the other form may be inactive (in which case it is wasteful to make both) or, more worryingly, it may have undesired side-effects such as toxicity. The work proposed here will enable to us to prepare these substructures as single mirror-image forms. In this way, not only are we developing more efficient and cleaner routes to potential new drug molecules, but we are also mimicking nature's own ability to make compounds as single mirror-image forms.
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Organisation Website: http://www.leeds.ac.uk