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Details of Grant 

EPSRC Reference: EP/C549406/1
Title: Agent-Based and Continuum Modelling of Populations of Cells
Principal Investigator: Logan, Professor B
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: School of Computer Science
Organisation: University of Nottingham
Scheme: Discipline Hopping Pre-FEC
Starts: 26 September 2005 Ends: 25 September 2006 Value (£): 38,682
EPSRC Research Topic Classifications:
Continuum Mechanics Fundamentals of Computing
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
EP/C549414/1
Panel History:  
Summary on Grant Application Form
Many biological problems involve a wide range of scales, from, say, an individual gene operating within a cell to a very large population of cells operating in concert. While the latter aspect is widely recognised in the context of distinct organs within the human body, for example, its significance in bacterial populations (associated with a phenomenon known as 'quorum sensing') has been appreciated only relatively recently. These advances, together with the increasing medical challenges arising from the development among bacteria of resistance to the available antibiotics, motivates efforts to understand such processes through the development of suitable mathematical models. These models should encompass the complex behaviour that occurs both within a single cell and at the level of the whole population of cells; to bridge these scales it is highly desirable that the models be able to incorporate very large numbers of cells, each of which has significant internal structure. The current project seeks to develop such models by combining the distinct skills of a computer scientist and a mathematical modeller in such a way that these challenges can be addressed.
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Organisation Website: http://www.nottingham.ac.uk