| EPSRC Reference: |
EP/C535502/1 |
| Title: |
High throughput biocatalytic synthesis and screening in micro reactors |
| Principal Investigator: |
Greenway, Professor G |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Hull |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 December 2005 |
Ends: |
30 November 2008 |
Value (£): |
204,984
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Bioprocess Engineering |
| Catalysis & Applied Catalysis |
Reactor Engineering |
| Separation Processes |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Food and Drink |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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The aim of this work will be to exploit the high surface to volume ratio and unique fluidic properties of micro reactors for the rapid optimisation of a variety of biocatalytic reactions. The micro reactors developed will be used to screen the enzymes in a high throughput manner, in order to investigate what other substrates the enzyme accepts. Many pharmaceutical companies require this methodology for the rapid delivery of semi-optimised biocatalytic processes in the early development of new drugs; this is often the limiting step in the application of biocatalytic reactions. The challenge is to develop a system capable of using enzymes to perform mufti-step reactions in microfluidic channels. This will allow the development of a synthetic toolkit to perform multi-step organic synthesis in a combined catalytic mode, without isolation of intermediates (the cascade principle). This ambitious approach replicates the highly efficient way in which enzymes are utilised within cells, as compared to treating them as individual chemical reagents. The development of a suitable micro reactor for combinatorial biocatalysis would be a significant advance and to achieve this ambition complementary in situ analysis will be vital.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.hull.ac.uk |