| EPSRC Reference: |
EP/C525906/1 |
| Title: |
Simplified Impedimetric-based Microarray platform for High Throughput at the Life/Physical Sciences Interface |
| Principal Investigator: |
Higson, Professor SPJ |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Cranfield University at Silsoe |
| Organisation: |
Cranfield University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
16 November 2004 |
Ends: |
15 June 2005 |
Value (£): |
17,550
|
| EPSRC Research Topic Classifications: |
| Analytical Science |
Chemical Biology |
| Fluid Dynamics |
Materials Characterisation |
|
| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
DNA microarray techniques set the goal standard for high throughput screening techniques - even though the approach necessitates fluorescent labelling, the use of lasers, are cumbersome and costly.This proposal seeks to build a consortium - who together will develop a platform technology to challenge conventional DNA microarray techniques. This technology will offer similar and potentially superior performance to conventional microarrays, while negating the use of fluorescent labels - by exploiting an electrochemical (impedance based) interrogation approach. Together these approaches promise far greater simplicity over conventional DNA microarray technology - and will offer cost savings, enhanced robustness and user friendliness to end users - all of which favours widespread application.These benefits will be achieved by:(i) monitoring electrochemically biological affinity based binding events, via...(ii) impedimetric approaches utilising...(iv) scanning micro-electrode based techniques, at...(v) spotted microarray plates- produced by photo-lithographic, screen printing and micro-jet spray techniquesAll of the key components are in place to develop a new generic platform technology that is a reality waiting to happen upon funding.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.cranfield.ac.uk |