| EPSRC Reference: |
EP/C520742/1 |
| Title: |
Functional Tissue Engineering of Osteo-Chondral Composites |
| Principal Investigator: |
Stevens, Professor M |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
Imperial College London |
| Scheme: |
First Grant Scheme Pre-FEC |
| Starts: |
01 September 2005 |
Ends: |
31 August 2007 |
Value (£): |
125,251
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Summary on Grant Application Form |
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Defects in articular cartilage can result in significant patient morbidity with initial clinical symptoms such as pain and joint dysfunction that can lead to the early onset of osteoarthritis, one of the most common of chronic diseases inflicting the adult population. There is a real clinical need for new treatment therapies for articular cartilage defects that allow for integration of new functional cartilage with the subchondral bone. This project aims to develop a novel approach to engineer large viable osteo-chondral (bone-cartilage) composites in vitro using principles of tissue engineering (TE). Periosteal tissue is a rich source of growth factors and stem cells for both bone and cartilage cells. In this project whole periosteal explants will be associated to 3-dimensional osteoconductive scaffolds. The periosteum itself will serve as a template for directional evolution of cartilage tissue above the scaffold whilst allowing periosteal cells that have infiltrated into the osteoconductive scaffold to form bone. The project will involve the investigation of the material and bioactive properties of suitable osteoconductive scaffolds, and detailed assessment of the functional nature
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |