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Details of Grant 

EPSRC Reference: EP/C509927/1
Title: Extreme sensitivity by engineering plasmon resonance sensors
Principal Investigator: Cumming, Professor DRS
Other Investigators:
Cooper, Professor J
Researcher Co-Investigators:
Dr A Glidle
Project Partners:
Department: Electronics and Electrical Engineering
Organisation: University of Glasgow
Scheme: Standard Research (Pre-FEC)
Starts: 02 May 2005 Ends: 01 November 2008 Value (£): 305,614
EPSRC Research Topic Classifications:
Cells Electronic Devices & Subsys.
Instrumentation Eng. & Dev. Microsystems
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology Chemicals
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
Adventure: This proposal aims to address the issue of developing very sensitive biological assays by exploring a new, and as yet unproven, technology that has the potential to deliver a very sensitive, label-less , generic sensor platform based on vibrational spectroscopy. Building upon our established background expertise in integrated optics and plasmons, we now seek to dramatically improve upon the current state-of-the-art by developing microand nano- fabricated light gathering devices that can be used to excite and detect vibrational modes in single biological entities, namely single molecules and single cells. The technology will, if successful, provide a series of tools that can be used to identify and characterise single molecules and their interactions in real-time, without the need for labels, amplification or sample processing. The techniques would have significant and wide reaching implications, particularly in proteomics, where one is particularly intereested in exploring the spatial and temporal changes in the distribution of receptors, ligands and other signalling molecules, within single cells.
Key Findings
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Potential use in non-academic contexts
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Impacts
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Summary
Date Materialised
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Further Information:  
Organisation Website: http://www.gla.ac.uk