| EPSRC Reference: |
EP/C011082/2 |
| Title: |
Using Transition Metal Catalysis to Achieve New Reactivity and Selectivity for Organic Synthesis |
| Principal Investigator: |
Willis, Professor M |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 2007 |
Ends: |
31 January 2009 |
Value (£): |
159,344
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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The ability to build molecules is crucial to molecular science. For new synthetic methods to be accepted as useful tools a demanding set of criteria need to be satisfied; advantages of cost, environmental impact, operational simplicity and reaction efficiency are some of the most important factors to be considered. The focus of this proposal is to develop new methods to prepare molecules using tools based on transition metal catalysts.The unique reactivities presented by transition metals make them attractive reagents to explore and to tackle several of the issues discussed above. In particular we plan to use transition metal catalysts to allow the conversion of readily available organic molecules into high value functionalised molecules useful for further manipulation. One of the key aims is to achieve these reactions in a highly selective manner, delivering only single products when the formation of mixtures of several related molecules is possible. We also plan to deliver methods that are easy to perform and that require no special handling techniques.The specific research conducted under this proposal will focus on developing a new reagent system that allows catalysts to reverse the normal reactivity of carbonyl groups. This type of polarity reversal will allow a wide range of reactions to be explored that are not accessible using standard catalyst methodology.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |