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Details of Grant 

EPSRC Reference: EP/C003497/1
Title: Mathematical modelling of growth characteristics in hierarchically structured tissue-engineered populations
Principal Investigator: Oreffo, Professor R
Other Investigators:
Please, Professor CP Packham, Professor G
Researcher Co-Investigators:
Professor BD MacArthur
Project Partners:
Department: Development Origin of Health and Disease
Organisation: University of Southampton
Scheme: Standard Research (Pre-FEC)
Starts: 04 April 2005 Ends: 03 April 2008 Value (£): 260,132
EPSRC Research Topic Classifications:
Development (Biosciences) Non-linear Systems Mathematics
Tissue Engineering
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
Stem cells reside in small numbers in most body tissues and control the healing processes subsequent to disease or injury. Bone marrow derived mesenchymal stem cells (MSCs) can produce various different tissue types including bone, cartilage and fat. However, the mechanisms by which different tissue types are produced from MSCs is very complex and therefore difficult to understand using intuition alone. Mathematical models provide a means to analyse complex systems such as the mesenchymal stem cell system. Therefore we propose an innovative approach to analyse how bone tissue is produced with the help of mathematical modelling in conjunction with experimentation. In particular we will use mathematical models to examine how gene expression correlates with stem cell activity and, significantly, how this correlation changes with age.
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Further Information:  
Organisation Website: http://www.soton.ac.uk