| EPSRC Reference: |
EP/C001788/1 |
| Title: |
Near Infrared Spectroscopy and Automatic Spectral Separation for Monitoring Particulate Speciality Chemical Processes: Study on a Pilot Plant Reactor |
| Principal Investigator: |
Wang, Professor X |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Inst of Particle Science & Engineering |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2005 |
Ends: |
30 June 2008 |
Value (£): |
71,321
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| EPSRC Research Topic Classifications: |
| Instrumentation Eng. & Dev. |
Particle Technology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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Despite being regarded as on-line chromatograph in some industrial applications such as petrochemical and biochemical industries, little work can be found on NIR application to particle formation processes. This is mainly due to the fact that, unlike mid IR, NIR spectra can be seriously affected by the presence of solid particles in the solution. This phenomenon is an indication that the NIR spectra contain more information regarding the solid properties than just concentration. We will investigate a new mathematical technique called independent component analysis (also known as blind source signal separation) for automatic separation of the spectra regarding concentration as well crystal polymorph properties, and in doing so develop a NIR on-line technique for simultaneous measurement of the properties of both liquid and slid phases for pharmaceutical crystallisation processes. The work will be conducted on an industrial-scale pilot plant reactor (200 litre) which was donated by AstraZeneca to the Institute of Particle Science and Engineering at Leeds.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |