Details of Grant 

EPSRC Reference:	EP/C001397/1
Title:	New Synthetic Technology: Enantioselective Organocatalysis
Principal Investigator:	Gaunt, Professor M
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Cambridge
Scheme:	First Grant Scheme Pre-FEC
Starts:	01 October 2004	Ends:	31 December 2007	Value (£):	125,281
EPSRC Research Topic Classifications:	Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
The use of catalysis to control the synthesis of architecturally complex molecules is a key aspect for the future of organic chemistry. Not only does this concept impact strongly on the arena of natural product synthesis but also the continued development of chemical biology, medicinal chemistry and materials science. The challenge for the synthetic chemist is to develop novel strategies for complex molecule synthesis that combine the factors of atom economy, catalysis and stereocontrol. This proposal aims to develop a new synthetic paradigm that utilises organic catalysts to produce an array of new enantioselective reactions based on a common chemical concept. Readily available organic molecules will provide the catalysts for these reactions enabling a single catalyst to perform an array of different reactions leading to a diversity of enantio- and diastereopure molecular architectures that will be used in natural product synthesis and chemical biology research programmes. The research aims to (A) develop organic molecule catalysed enantio- and diastereoselective reactions that form a diverse range of molecular architectures from readily available building blocks; (B) explore applications in the total synthesis of bioactive natural products.Innovative strategies for natural product synthesis using our enantioselective reactions as the key steps in combination wilth elegant cascade processes that enable a rapid assembly of these complex targets will also be explored. The proposal targets highly important and challenging problems in synthetic chemistry.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.cam.ac.uk