| EPSRC Reference: |
EP/X025446/1 |
| Title: |
Smart biomanufacturing for genomic medicines |
| Principal Investigator: |
Bracewell, Professor DG |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Biochemical Engineering |
| Organisation: |
UCL |
| Scheme: |
Standard Research |
| Starts: |
01 May 2024 |
Ends: |
30 April 2029 |
Value (£): |
1,255,304
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| EPSRC Research Topic Classifications: |
| Biochemical engineering |
Development (Biosciences) |
| Drug Formulation & Delivery |
Genomics |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Healthcare |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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15 Nov 2022
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Prosperity Partnership Round 5 Full Proposal
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Announced
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Summary on Grant Application Form |
This partnership builds on the existing Pall-UCL Centre of Excellence collaboration which is carrying out fundamental research to address biomanufacturing industry needs. It brings together Pall (a global integrated separations solutions supplier to the Life Sciences and industrial sectors) and UCL Biochemical Engineering (a world leader in bioprocess research creating novel engineering solutions to underpin future biomanufacturing operations across a range of sectors) in a research collaboration to address the challenges of manufacturing next generation biological medicines. These therapies are made possible by the delivery of genetic molecules to the site of disease to control protein production in cells and tissue. The current toolbox of genetic molecules includes small interfering ribonucleic acid (siRNA), messenger RNA (mRNA), self-amplifying RNA (SAM), deoxyribonucleic acid (DNA) and gene editing components such as guide RNA (gRNA), ribonucleoprotein (RNP) and nucleases. Delivery is made possible using a variety of vectors including lipid nanoparticles, virus and extracellular vesicles / exosomes. This field of personalised genetic medicine has seen unprecedented growth in over the last decade. In 2021 the gene therapy global market was estimated at £622M with 25% year on year growth and over £10 billion invested in development of the sector.
The UK is a world leader in life science discovery but traditionally this does not translate into revenue generation for the UK via manufacture. This generation of new more complex biological therapies offers the opportunity for the UK to convert its lead in medicines discovery to manufacturing. To take these therapies to market will require specialist NHS-type resource for proof of principle and the scale of manufacture of these new therapies is particularly suited to Pall's specialisation in small-scale rapid response units for manufacture. The Prosperity Partnership is designed to help complete the continuum from life science discovery to manufactured therapies for the patient bringing together UCL bioprocess discoveries and Pall UK's specialism in novel manufacturing units around these new classes of complex personalised biological medicines.
The partnership will be managed by a joint Pall-UCL management committee led by Dr John Welsh for Pall and Prof. Daniel Bracewell for UCL. The committee is constituted of senior leaders with the necessary experience to steer the partnership during its lifetime and update the focus of the research with the fast-moving nature of the bioprocessing sector.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
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