Details of Grant 

EPSRC Reference:	EP/R013772/1
Title:	Dynamics in DOPC: muon hyperfine coupling constants for an 18:1 delta-9 cis chain
Principal Investigator:	Clayden, Dr NJ
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of East Anglia
Scheme:	Overseas Travel Grants (OTGS)
Starts:	15 September 2017	Ends:	14 December 2017	Value (£):	3,720
EPSRC Research Topic Classifications:	Biophysics
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
The action of inert anaesthetic gases such as Xe and N2O is still unclear, particularly as these will have only weak interactions with receptors implicated in small molecule anaesthesia. One possibility is an indirect effect through changing the dynamics of the membrane in which the receptors are embedded. Recent experiments at the RAL-ISIS muon facility have demonstrated that the muon can be used as an external probe for the dynamics of phospholipid bilayers used as a model membrane. Further muon experiments are however required at PSI, a continuous muon source, in order to complete the analysis of the earlier data and allow a full interpretation of the changes seen in the muon spectra. The experiments at PSI will yield the muon hyperfine coupling constant enabling complete assignment of the ALC-MuSR spectra seen when the phospholipid bilayer is exposed to Xe or N2O.
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Organisation Website:	http://www.uea.ac.uk