| EPSRC Reference: |
EP/R006482/1 |
| Title: |
New Microsystems for Antimicrobial Resistance |
| Principal Investigator: |
Jimenez, Dr M |
| Other Investigators: |
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| Department: |
College of Science and Engineering |
| Organisation: |
University of Glasgow |
| Scheme: |
EPSRC Fellowship |
| Starts: |
19 November 2017 |
Ends: |
29 November 2018 |
Value (£): |
357,335
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| EPSRC Research Topic Classifications: |
| Med.Instrument.Device& Equip. |
Microsystems |
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Summary on Grant Application Form |
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The latest estimates, published by the Government and The Wellcome Trust, predict that by 2050 antimicrobial resistance (AMR) could claim one life every three seconds, higher than the current death rates for cancer (http://amr-review.org). Many factors can be attributed to the emergence of AMR associated with medical practice, agricultural policy and deficiencies in education/global awareness. A major limitation, evidenced through the recent launch of the £10M Longitude Prize (2015-2019), is in the lack of fast and reliable diagnostic technologies. For example, current methods to identify an infection in blood are based on bacteria culture and require several days to establish a positive result. During this interim period, potentially ineffective broad-spectrum antibiotics are often administered. Consequently, the development of new diagnostic tools is now seen as one of the four main priorities to address AMR (the other being increasing public awareness, developing new drugs and decreasing the use of antibiotics in agriculture). My Fellowship aims to tackle the challenge of personalized diagnosis by engineering a suite of new advanced microsystems capable of performing a fast, user-friendly isolation of microbes for detection. I will combine improved microfluidic-based separation approaches with innovative ultrasonic concentration technologies to isolate harmful agents in volumes of fluids that are small enough to promote the use of advanced diagnostic tools such as next-generation genome sequencing. These technologies have the potential to reduce unnecessary administration of inappropriate antibiotics, enabling a targeted or personalised approach (consistent with the aims of "precision medicine").
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |