| EPSRC Reference: |
EP/N006615/1 |
| Title: |
Next Generation Biomaterials Discovery |
| Principal Investigator: |
Alexander, Professor MR |
| Other Investigators: |
| Tuck, Professor CJ |
Denning, Professor C |
Grabowska, Professor A |
| Rose, Professor FRA |
Davies, Professor M |
Shakesheff, Professor K |
| Hague, Professor RJ |
Alexander, Professor C |
Kim, Dr D |
| Irvine, Professor DJ |
Bunch, Professor J |
Ghaemmaghami, Professor AM |
| Merry, Professor C |
Howdle, Professor S |
Williams, Professor PM |
| Wildman, Professor R |
Williams, Professor P |
Yang, Dr J |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Sch of Pharmacy |
| Organisation: |
University of Nottingham |
| Scheme: |
Programme Grants |
| Starts: |
09 November 2015 |
Ends: |
31 July 2022 |
Value (£): |
5,365,958
|
| EPSRC Research Topic Classifications: |
| Drug Formulation & Delivery |
Materials Characterisation |
| Materials Synthesis & Growth |
Med.Instrument.Device& Equip. |
| Tissue engineering |
|
|
| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
Advanced biomaterials are essential components in targeting infectious diseases and cancers, realising the potential of regenerative medicine and the medical devices of the future. A multidisciplinary team spanning Engineering, Science and Medical Faculties in Nottingham, in collaboration with 4 leading international groups has combined to realise the vision of materials discovery in 3D. Without this leap beyond 2D screening methodologies we will miss new advanced materials because they omit architecture and often poorly represent the in vivo environment. The aim is to allow us to move beyond the existing limited range of generic bioresorbable polymeric drug and cell delivery agents currently licensed for use in man and medical device polymers, to bespoke materials identified to function optimally for specific applications.
We know that defining chemistry, stiffness, topography and shape can control the response of cells to materials. This programme will focus on producing and testing large libraries of these attributes in the form of patterned surfaces, particles and more complex architectures. New materials will be identified for application in the areas of targeted drug delivery, regenerative medicine and advanced materials for next generation medical devices.
The 3D screening methods will define a new landscape in biomaterials discovery and create the platforms through which more effective advanced materials will be discovered. Our three ambitious application focussed areas provide high impact examples in which our biomaterials leads are developed towards exploitation in the clinic. These downstream projects will be carried out in both academic and commercial research programmes funded through partnering, licensing and formation of spin-outs as appropriate.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.nottingham.ac.uk |