| EPSRC Reference: |
EP/I003398/1 |
| Title: |
CH--O Hydrogen-Bonds as Structural Elements for Synthesis and Catalysis |
| Principal Investigator: |
Smith, Professor MD |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research |
| Starts: |
28 April 2011 |
Ends: |
27 April 2014 |
Value (£): |
364,062
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| EPSRC Research Topic Classifications: |
| Chemical Structure |
Protein folding / misfolding |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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30 Sep 2010
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NSF/EPSRC Chemistry Proposals 2009
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Announced
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Summary on Grant Application Form |
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Nature has evolved large and complex molecules - proteins - which are comprised of simple building blocks that fold into specific three-dimensional shapes. These folded molecules are important for mediating many physiological chemical reactions. We are interested in examining the weak interactions that hold these molecules in their precise three-dimensional shape, and attempting to replicate them in simple synthetic systems. This involves the design and synthesis of molecules designed to fold into specific shapes, and simulation of their properties using high-level quantum calculation. The insight provided by these calculations will allow us to understand the forces that shape the properties of these small, designed molecules, and will also permit us to potentially emulate the exquisite specificity and reactivity exhibited by natural systems. We hope that this understanding will allow us to develop small, functional molecules that emulate some of the desirable properties of proteins.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |