| EPSRC Reference: |
EP/G041431/1 |
| Title: |
ortho-Quinone Methides in Natural Product Synthesis |
| Principal Investigator: |
Bray, Dr C |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Biological and Chemical Sciences |
| Organisation: |
Queen Mary University of London |
| Scheme: |
First Grant Scheme |
| Starts: |
01 October 2009 |
Ends: |
31 July 2013 |
Value (£): |
232,826
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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20 Jan 2009
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Chemistry Prioritisation Panel January
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Announced
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Summary on Grant Application Form |
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Some years ago, the predominant view of benzynes, carbenes and radicals was that they were uncontrollably reactive and so could not be used in the construction of complex natural products. This perception has of course changed and such species are now routinely employed in synthesis. It can be argued that such a view is still held of ortho-quinone methides (o-QMs). These species have long been documented and much is known about how Nature utilises their high reactivity. For example, they are released as a means of defence by plants and insects whereas oxidation of vitamin E and dimerisation of the resultant ortho-quinone methides is used by the body as a storage mechanism. Also, the therapeutic benefit of a number of important chemotherapy drugs is based upon their ability to form an ortho-quinone methide in vivo. Despite this widespread use in biological systems, the application of ortho-quinone methides in total synthesis is extremely limited. The current program of research will look to develop the chemistry of ortho-quinone methides such that they can then be applied in the total synthesis of some biologically important molecules. The research will contribute to our fundamental knowledge of the chemistry of ortho-quinone methides and will promote the benefits of these highly useful species in all branches of synthetic chemistry.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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