| EPSRC Reference: |
EP/G026882/1 |
| Title: |
Improved Liquid and Mixed Metal Activation for Organic Synthesis |
| Principal Investigator: |
Woodward, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research |
| Starts: |
15 January 2009 |
Ends: |
14 January 2012 |
Value (£): |
342,388
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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01 Oct 2008
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Chemistry Prioritisation Panel (Science)
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Announced
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Summary on Grant Application Form |
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This present application represents a revised immediate resubmission of EP/G00272X/1 (considered early June 2008) it was highly rated but insufficient funds were available to the prioritisation panel. Referee comments on the lead science in this application were very strong (e.g. 'most novel and refreshing proposal I haves seen', 'truly excellent ideas', 'outstanding', etc.) but the funding environment did not allow its support.We have found that catalytic liquid gallium can be used for highly efficient unprecedented metal activation allowing simplified rapid preparation of organometallics RM and metal hydrides. The technique allows formation of new unprecedented air-stable aryl alanes; direct use metal-mixtures for improved/efficient RX and hydrogen and amine activation to provide Al-hydrides [HAl(NR2)2] and [HAl(NR2)Cl] and the DABCO stabilized air-stable organometallics [(RnY3-n)2(DABCO)] (Y = I, NR2). These derived reagents are to be used in fast throughput (asymmetric) screening of 1,2-additions to FG-RCHO and imines; 1,4-additions to unsaturated acylcyanides; alkene and alkyne hydroalumination and their subsequent use in related processes.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |