| EPSRC Reference: |
EP/F069731/1 |
| Title: |
Light Efficient Detection in Sectioning Biological Microscopy (EDIM) |
| Principal Investigator: |
Heintzmann, Dr R |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Randall Div of Cell and Molecular Biophy |
| Organisation: |
Kings College London |
| Scheme: |
First Grant Scheme |
| Starts: |
16 March 2009 |
Ends: |
15 September 2012 |
Value (£): |
410,970
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| EPSRC Research Topic Classifications: |
| Cells |
Instrumentation Eng. & Dev. |
| Med.Instrument.Device& Equip. |
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| EPSRC Industrial Sector Classifications: |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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24 Jun 2008
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Healthcare Engineering Panel (Eng)
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Announced
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Summary on Grant Application Form |
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This project aims at developing and testing a novel detection technique, which will enhance the light-efficiency of confocal microscopes in combination with enhanced spatial resolution. Achieving high spatial resolution in an ordinary confocal microscope requires closing a pinhole in front of the detector to a very small size, which inevitably leads to substantial loss of light. In contrast, the proposed detection technique can achieve even better resolution with a light throughput performance typical for relatively open pinholes. Also the out-of-focus suppression will be enhanced. This idea promises a substantial improvement over existing technology, but has so far not practically been realized. The optical scheme, to employ is based on the use of an image-inversion interferometer, which is very different in spirit from previous attempts using aperture modifying filters.The project will build a prototype to demonstrate and evaluate these concepts and also an extension, which will allow high resolution imaging in a projection mode (extended focus imaging).
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
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