| EPSRC Reference: |
EP/E025080/1 |
| Title: |
Umpolung in 'Michael' Chemistry |
| Principal Investigator: |
Woodward, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Nottingham |
| Scheme: |
Standard Research |
| Starts: |
15 January 2007 |
Ends: |
14 January 2009 |
Value (£): |
204,403
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Abstract: The chemistry of enamine N-oxides has only ever been investigated twice since the dawn of modern organic synthesis. We are going to use these rare species to reverse the polarity of the intermediate in a classical example of a Michael (1,4-addition) reaction. This unprecedented change in polarity will allow the rapid synthesis of densely functionalized organic intermediates through the addition of two sequential nucleophiles. Chiral fragments (including amines, aminoacids, aminoalcohols, etc.) of use in natural product and advanced pharmaceutical synthesis will be prepared. The latter sector is one of the fastest growing in the world fine chemical market (~4 billion p.a. with growth of ~10% yr-1).
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |