| EPSRC Reference: |
EP/C548604/1 |
| Title: |
The Intermolecular Pauson-Khand Reaction |
| Principal Investigator: |
Gibson, Professor SE |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2005 |
Ends: |
30 September 2008 |
Value (£): |
124,540
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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The demand for increasingly more efficient and effective pharmaceuticals needs to be met by increasingly more efficient and effective methods of making these molecules. Many pharmaceuticals are chiral, which means that they exist as two mirror images. These mirror images often behave quite differently in their interactions with the body's complex chemistry, and so it is important for safety and economic reasons to make pharmaceuticals in just one of its two forms i.e. the one which has the best clinical effect. One of the most efficient ways of doing this is by using a small amount of a chiral catalyst, ultimately derived from chirality created by nature, to generate large amounts of a key molecule en route to the target pharmaceutical. In this project we plan to design and develop new catalytic and chiral systems for a reaction that joins alkynes, alkenes and carbon monoxide together to make cyclopentenones, important building blocks for a wide range of pharmaceuticals and fine chemicals.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |