| EPSRC Reference: |
EP/C546679/1 |
| Title: |
Identification of colloid science routes to improve the critical performance of tamponade agents |
| Principal Investigator: |
Williams, Professor R |
| Other Investigators: |
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| Department: |
Clinical Sciences |
| Organisation: |
University of Liverpool |
| Scheme: |
Postdoctoral Mobility PreFEC |
| Starts: |
01 August 2005 |
Ends: |
31 July 2006 |
Value (£): |
65,217
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Summary on Grant Application Form |
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Retinal detachments occur for a number of reasons and if untreated will lead to blindness. Tamponade agents are used in the treatment of retinal detachments. They are injected into the back of the eye to replace the patients vitreous. The tamponade agent advocated for use in patients with complex retinal detachments, for example those complicated by systemic disease such as diabetes, is silicone oil. Although several studies have shown that silicone oil is clinically effective and acceptable for this application problems with its use have been identified. One of these is that the silicone oil emulsifies resulting in small droplets of oil surrounding the main bubble. These droplets can cause significant adverse biological responses as well as reduce the effectiveness of the tamponade agent and interfere with the patients vision. We hypothesise that we can reduce the risk of emulsification by increasing the extensional viscosity of the silicone oil without causing large increases in the shear viscosity and therefore without making it more difficult for the vitreoretinal surgeons to use. This study will use colloid science expertise to study the emulsification of silicone oil tamponade agents and explore routes to reduce this process.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.liv.ac.uk |