Details of Grant 

EPSRC Reference:	EP/C512731/1
Title:	Ultrasound Stimulated Crystallisation Of Polymorphic Materials
Principal Investigator:	Ristic, Dr R
Other Investigators:	Martin, Dr CM Tang, Dr C
Researcher Co-Investigators:
Project Partners:
Department:	Chemical & Biological Engineering
Organisation:	University of Sheffield
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2005	Ends:	30 September 2008	Value (£):	258,327
EPSRC Research Topic Classifications:	Particle Technology
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:	Panel Date Panel Name Outcome 09 Nov 2004 Engineering Science (Flow) Panel Deferred
Summary on Grant Application Form
The overall aim of the proposed research is to establish sound scientific principles to guide kinetics of polymorphic transformations and selection of a desired polymorph via application of ultrasound irradiation. Our preliminary experiments suggests that these priniciples can be achieved by uderstanding the fundamentals of phase transformation of molecular solids whose solution/melt is subjected to a controllable sonication, at well defined conditions of temperature and supercooling/supersaturation of a liquid. This research proposal addresses this issue by studying crystallisation behaviour with and without application of ultrasonic power to the liquid of a typical solution-grown and melt-grown polymorphic materials by using in-sit synchrotron radiation time-resolved small angle X-ray scattering (SAXS) and wide angle X-ray scattering (WAXS). In parallel, simpler and considerably cheaper laboratory (conventional) experiments will be used to characterise the polymorphic behaviour of the same materials under the same conditions as those at SRS. The validity of the conventional approach, and hence its potential applicability for controlling polymorphic behaviour, will be tested by comparing the results with those obtained with time-resolved SAXS/WAXS data collected at central facilities. A scale-up of crystallisers and quality of precipitated product obtained with and without sonication will be also investigated.
Key Findings
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Organisation Website:	http://www.shef.ac.uk