Details of Grant 

EPSRC Reference:	EP/C510100/1
Title:	Development and utilisation of sulfimide derivatised macrocyclic systems
Principal Investigator:	Kelly, Professor P
Other Investigators:	Reid, Professor G
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	Loughborough University
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2005	Ends:	30 September 2007	Value (£):	124,586
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology Co-ordination Chemistry
EPSRC Industrial Sector Classifications:	Chemicals
Related Grants:
Panel History:	Panel Date Panel Name Outcome 21 Oct 2004 Chemistry Prioritisation Panel (Science) Deferred
Summary on Grant Application Form
Macrocyclic systems based upon thio (and, to a lesser extent, seleno) ether linkages have a long and productive history, both in terms of the range of compounds known and in terms of the metal coordination chemistry they can exhibit. Progress in this area has tended to come through the careful control of preparative routes, allowing the exact nature of the cyclic product to be engineered during the cyclisation process. The idea of signifcantly tailoring the macrocycle's properties after cyclisation is very appealing, but this has yet to be implemented to any significant degree. This project aims to address this by developing an a new strategy for the controlled, post ring-closure, derivatisation of a range of macrocyclic system bearing thio and seleno ether linkages. In essence it hinges on taking ligands known to be very effective at binding metal centres and altering their properties via reactions at one or more of the sulfur (or selenium) atoms. Key to this chemistry is the fact that the sulfimidation (or selenimidation) process will not only produce products with altered chemical and physical properties (eg allowing aqueous chemistry), but will also then allow us to undertake further chemistry and generate a range of totally new system eg by linking together multiple crowns, adding heteroatoms to act as pendant arms, tethering the crowns to supports etc.
Key Findings
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Project URL:
Further Information:
Organisation Website:	http://www.lboro.ac.uk