Details of Grant 

EPSRC Reference:	EP/C015657/1
Title:	Silylated Dienes as Versatile Precursors of Fluorinated Carbo- and Heterocycles
Principal Investigator:	Gouverneur, Professor V
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Oxford Chemistry
Organisation:	University of Oxford
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2005	Ends:	31 March 2009	Value (£):	111,438
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:	Healthcare Pharmaceuticals and Biotechnology
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Panel History:
Summary on Grant Application Form
Fluorine continues to intrigue chemists who overcome the challenge of handling this remarkable halogen and work to develop varied methods for synthesising fluorine compounds. The unique properties of these materials, ranging from inert perfluorocarbons and fluoropolymers to a multitude of other fascinating fluorinated compounds, firmly established their place within the technological achievements of the 20th Century. Fluorine substitution in biologically active compounds has become particularly significant in recent years. Indeed, up to 20% of new drug molecules in clinical trials contain one or more fluorine atoms. The chemistry that we proposed to develop will allow the preparation of numerous fluorinated cyclic targets expanding the repertoire of synthetic sequences available for the preparation of these highly valuable compounds. This chemistry combines a very powerful well-known reaction, a cycloaddition process, with a transformation developed within our laboratory the electrophilic fluorodesilylation. The versatility of this approach will allow the production of various cyclic fluorinated carbo- and heterocycles possessing up to six sterocentres of defining stereochemistry. The impact within industrial and biomolecular communities will be significant as they are still few methods of solving the problem that we propose to address. Our proposed research culminates with an alternative approach to an intermediate toward the synthesis of a fluorinated analogue of vitamin D, a family of compounds displaying remarkable biological properties such as potential use for the treatment of leukemia.
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Organisation Website:	http://www.ox.ac.uk