| EPSRC Reference: |
EP/C003497/1 |
| Title: |
Mathematical modelling of growth characteristics in hierarchically structured tissue-engineered populations |
| Principal Investigator: |
Oreffo, Professor R |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Development Origin of Health and Disease |
| Organisation: |
University of Southampton |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
04 April 2005 |
Ends: |
03 April 2008 |
Value (£): |
260,132
|
| EPSRC Research Topic Classifications: |
| Development (Biosciences) |
Non-linear Systems Mathematics |
| Tissue Engineering |
|
|
| EPSRC Industrial Sector Classifications: |
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
Stem cells reside in small numbers in most body tissues and control the healing processes subsequent to disease or injury. Bone marrow derived mesenchymal stem cells (MSCs) can produce various different tissue types including bone, cartilage and fat. However, the mechanisms by which different tissue types are produced from MSCs is very complex and therefore difficult to understand using intuition alone. Mathematical models provide a means to analyse complex systems such as the mesenchymal stem cell system. Therefore we propose an innovative approach to analyse how bone tissue is produced with the help of mathematical modelling in conjunction with experimentation. In particular we will use mathematical models to examine how gene expression correlates with stem cell activity and, significantly, how this correlation changes with age.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.soton.ac.uk |