| EPSRC Reference: |
DT/E010857/1 |
| Title: |
Exploitation of surface plasmon resonance imaging for two dimensional smart cell screening |
| Principal Investigator: |
Ray, Professor A |
| Other Investigators: |
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| Department: |
Materials |
| Organisation: |
Queen Mary University of London |
| Scheme: |
Technology Programme |
| Starts: |
01 May 2007 |
Ends: |
30 April 2009 |
Value (£): |
208,096
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| EPSRC Research Topic Classifications: |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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A motion free wavelength selective imaging surface plasmon resonance system will be developed to visualise the broader metabolically driven and cytoskeletal charges of surface captured cells in response to stimuli creating a broadly applicable screening tool for optimisation of a wide range of bioprocesses. The proposed system is innovative in design in that it has no moving parts and novel in application in that it will enable cell surface contact charges to be monitored simultaneously for a (heterogeneous) population of surface adherent cells. When response to a pre-selected external stimulus (e.g. enzyme substrate) is registered by a specific cellsub-group at the surface, then that cell group provides a preselected panel for further optimisation for a particular receptor or enzyme cascade. It is envisaged that the system will have application in the discovery of environments conducive to a diverse range of bioprocessing and the robustness would lend itself to integration with the bioprocesses for feedback control and bio-optimisation.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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