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EPSRC Support by Research Area (Chemical Biology and Biological Chemistry) in Theme (Physical Sciences)

Research areas are used to describe EPSRC's portfolio of excellent long term research and high quality postgraduate training.

Grants are classified using one or more research areas. The number and value of grants listed below reflects how the theme portfolio is described by this research area.

Please note: some research areas will appear under multiple themes. There is no unique, absolute, relationship between a research area and a theme.

Grant TitlePrincipal
Investigator
OrganisationDepartmentTotal Grant
Value (£)
A new tool to support drug discovery: Native LESA mass spectrometry (NESA)Cooper, Professor HJUniversity of BirminghamSch of Biosciences 411,030
A Protein Functionalization Platform Based on Selective Modification at Methionine ResiduesGaunt, Professor MUniversity of CambridgeChemistry 1,892,760
Aberration-Corrected Scanning Transmission Electron Microscope with atomic resolution spectroscopy under controlled environmental conditions: AC-eSTEMLazarov, Dr VUniversity of YorkPhysics 3,250,534
An Artificial RibosomeTurberfield, Professor AJUniversity of OxfordOxford Physics 664,201
An Artificial RibosomeO'Reilly, Professor RKUniversity of BirminghamSchool of Chemistry 581,943
An EPSRC National Research Facility to facilitate Data Science in the Physical Sciences: The Physical Sciences Data science Service (PSDS)Coles, Professor SJUniversity of SouthamptonSch of Chemistry 2,996,067
Anti tumour agents from natural products - new approaches to targeting ultra potent analogues of the duocarmycinsSearcey, Professor MUniversity of East AngliaPharmacy 450,207
Autonomous Discovery of Functional Small MoleculesNelson, Professor ASUniversity of LeedsSch of Chemistry 1,245,808
Bioorthogonal Gold Chemistry to Explore Novel Biomedical ApplicationsUnciti-Broceta, Professor AUniversity of EdinburghEdinburgh Cancer Research Centre 513,211
Chemical biology tools for investigating the chemistry of cellular REDOX stressConway, Professor SJUniversity of OxfordOxford Chemistry 5,334,387
Chemical probes to decode the subcellular redox-regulated proteomeWright, Dr MHUniversity of LeedsSch of Chemistry 277,691
Chemical Tools for Probing Histone Deacetylase Multiprotein Complexes in DiseaseHodgkinson, Dr JTUniversity of LeicesterChemistry 246,269
Cloud-based methods to predict the druggability of protein-protein interactions: applications to cancer and antimicrobial resistance.Laughton, Professor CUniversity of NottinghamSch of Pharmacy 293,994
Controlling membrane translocation for artificial signal transductionWilliams, Professor NHUniversity of SheffieldChemistry 356,411
Controlling Membrane Translocation for Artificial Signal TransductionHunter, Professor CAUniversity of CambridgeChemistry 405,953
CRISPR ChemistryBrown, Professor TUniversity of OxfordOxford Chemistry 254,184
Designer Chemistry to Probe Supramolecular Assembly Mechanism and FunctionWilson, Professor AJUniversity of LeedsSch of Chemistry 458,233
Diversity-Oriented Synthesis of Stapled PeptidesSpring, Professor DUniversity of CambridgeChemistry 1,205,345
Efficient modelling and validation of cryptic protein binding sites for drug discoveryMichel, Dr JUniversity of EdinburghSch of Chemistry 198,251
Efficient modelling and validation of cryptic protein binding sites for drug discoveryGervasio, Professor FUCLChemistry 272,316
EPSRC UK National Crystallography ServiceColes, Simon JohnUniversity of SouthamptonSchool of Chemistry 4,680,553
Establishing a Design Blueprint for Nanomedicines for Oral Drug DeliveryVllasaliu, Dr DKings College LondonPharmaceutical Sciences 82,118
Evaluation of Potential of Zwitterionic Salts for the Development of Protein-Resistant SurfacesBlesic, Dr MQueen's University of BelfastSch of Chemistry and Chemical Eng 110,174
Expanding the biochemical toolbox for protein modification at cysteineMacMillan, Dr DUCLChemistry 375,298
Exploration of Linking Chemistry in the Design of Aptamer-Molecularly Imprinted Polymer Hybrids (aptaMIPs)Turner, Dr NWDe Montfort UniversitySchool of Pharmacy 296,003
FINESSE NanoBio (Fabrication and Imaging of Neon-Etched Structures and Surfaces for Engineering, Nanoscience and Biotechnology)Daly, Dr RUniversity of CambridgeEngineering 2,427,240
Hydrophobic Gating in Membrane Nanopores: Water at the NanoscaleSansom, Professor MUniversity of OxfordBiochemistry 379,691
Immuno-chemotherapeutic Metal Complexes for Cancer Stem Cell-Directed TherapySuntharalingam, Dr KUniversity of LeicesterChemistry 217,731
Integrated computational and synthetic tools to drive the discovery of orthosteric protein-protein interaction inhibitorsWilson, Professor AJUniversity of LeedsSch of Chemistry 2,751,527
Ion Beam Analysis for the 2020's and Beyond: An Integration of Elemental Mapping and 'omics'Bailey, Dr MJUniversity of SurreyChemistry 1,025,483
Lanthanide complexes as chiral probes and labelsParker, Professor DDurham, University ofChemistry 582,868
Luminescent Host Molecules for Multisite Recognition of Polyphosphate AnionsButler, Dr SJLoughborough UniversityChemistry 247,277
Metal-free couplings for molecules, materials and bioactive targetsProcter, Professor DJUniversity of Manchester, TheChemistry 1,146,757
Meta-Smart: Merging de novo designed biomolecules with plasmonic metamaterials for new technologiesKadodwala, Professor MUniversity of GlasgowSchool of Chemistry 1,022,161
Modify-catch-release-repeat: Reversible bioconjugations for controlled release of small molecules from antibodies and their fragmentsFascione, Dr M AUniversity of YorkChemistry 397,840
Molecular Switches as Sensors for Kinase ActivityThomson, Dr AUniversity of GlasgowSchool of Chemistry 98,151
NAMS: Native ambient mass spectrometryCooper, Professor HJUniversity of BirminghamSch of Biosciences 1,241,472
Nanoanalysis for Advanced Materials and HealthcareMartin, Professor RWUniversity of StrathclydePhysics 13,061
Nanoscale metallomics and mineralization: advanced spectro-microscopy determination of the role of iron and calcium in Alzheimer's diseaseCollingwood, Dr JFUniversity of WarwickSch of Engineering 418,210
Nanoscale metallomics and mineralization: advanced spectro-microscopy determination of the role of iron and calcium in Alzheimer's diseaseTelling, Professor NDKeele UniversityInst for Science and Tech in Medicine 337,549
New Directions in Bioisostere ResearchAnderson, Professor EAUniversity of OxfordOxford Chemistry 572,768
New Reagents for Protein ModificationBaud, Dr MUniversity of SouthamptonSch of Chemistry 195,281
Next generation molecular imaging and therapy with radionuclidesBlower, Professor PKings College LondonImaging & Biomedical Engineering 6,437,106
Nicotinic Ligand Development to Target Smoking Cessation and Gain a Molecular Level Understanding of Partial AgonismGallagher, Professor TUniversity of BristolChemistry 724,553
One size fits all: The semi-synthesis of new undecaprenol analogues for the study of multiple undecaprenyl-processing enzymesCochrane, Dr SQueen's University of BelfastSch of Chemistry and Chemical Eng 215,788
Partially fluorinated alkyl motifs for pharmaceuticals and agrochemicals researchO'Hagan, Professor DUniversity of St AndrewsChemistry 424,425
PET Markers of Oligomeric Misfolded Proteins in Neurodegenerative DisordersAigbirhio, Professor FIUniversity of CambridgeWolfson Brain Imaging Centre 1,041,821
Poised Fragment Libraries for Atypical Bromodomain InhibitionSpencer, Professor JUniversity of SussexSch of Life Sciences 428,829
Properties and applications of Janus faced fluorocyclohexanesO'Hagan, Professor DUniversity of St AndrewsChemistry 482,983
Property-Enhanced PorphyrinsChauvet, Dr A A PUniversity of SheffieldChemistry 379,306
Singlet Fission in Carotenoid Aggregates (SIFICA)Clark, Dr JUniversity of SheffieldPhysics and Astronomy 851,312
Singlet Fission in Carotenoid Aggregates (SIFICA)Barford, Professor WUniversity of OxfordOxford Chemistry 294,636
Site-selective antibody modification by cysteine-to-lysine transfer (CLT)Baker, Dr JRUCLChemistry 411,777
Site-selective functionalisation of peptides and proteins via free-radical-induced dechalcogenationMitchell, Dr NJUniversity of NottinghamSch of Chemistry 428,349
Software for experimentally driven macromolecular modellingDegiacomi, Dr MDurham, University ofChemistry 687,453
Structural dynamics and photoinduced electron transferVlcek, Professor AQueen Mary University of LondonSch of Biological and Chemical Sciences 649,756
Structural Dynamics in LOV Domain Photosensor ProteinsMeech, Professor SUniversity of East AngliaChemistry 352,953
Substrate Peptidomimetic Inhibitors (SPIs) of the COP9 signalosomeKessler, Dr BMUniversity of OxfordTarget Discovery Institute 116,018
Substrate Peptidomimetic Inhibitors (SPIs) of the COP9 signalosomeJamieson, Dr AUniversity of GlasgowSchool of Chemistry 189,897
Supramolecular Designs on Dynamic Covalent Protein RecognitionThompson, Dr SUniversity of SouthamptonSch of Chemistry 244,859
Switching On and Powering Molecular Machines: Ultrafast Dynamics of PhotoswitchesMeech, Professor SUniversity of East AngliaChemistry 362,388
Synthesis and Biology of ProstanoidsAggarwal, Professor VKUniversity of BristolChemistry 1,061,277
Synthesis and characterisation of DNA adducts derived from the bracken toxin ptaquiloside.Williams, Dr DUniversity of SheffieldChemistry 354,312
Synthesis of the RNA polymerase inhibitor tagetitoxinPorter, Dr MJUCLChemistry 389,768
The Realisation of Fragment-Oriented SynthesisMarsden, Professor SPUniversity of LeedsSch of Chemistry 574,490
Triple Imaging with PARASHIFT ProbesParker, Professor DDurham, University ofChemistry 370,028
Triple Imaging with PARASHIFT ProbesBlamire, Professor AMNewcastle UniversityInstitute of Cellular Medicine 238,021

Total Number of Grants: 67
Total Value of Grants: £57,640,111

The grant value may include the cost of access to facilities (these funds are not awarded to the grant holding organisation).