| EPSRC Reference: |
GR/M94885/01 |
| Title: |
SURFACES TO ENHANCE TISSUE CULTURE OF SKIN |
| Principal Investigator: |
Short, Professor R |
| Other Investigators: |
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| Department: |
Materials Science and Engineering |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
04 October 1999 |
Ends: |
03 July 2003 |
Value (£): |
116,630
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Summary on Grant Application Form |
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This proposal is concerned with defining the optimal surfaces for the tissue culture of keratinocytes (skin cells). Keratinocyte attachment, proliferation and differentiation will be examined upon molecularly engineered plasma co-polymer surfaces. We will explore the interplay between specific surface functional groups and cell behaviour. Self assembeled monolayers will be used to validate the _esults. This will lead to an understanding of the functionalities responsible for aspects of cellular behaviour and allow the optimum surfaces for cell culture to be produced. Such surfaces will be of importance in the tissue engineering of skin. For example surfaces which promote proliferation will assist in cell multiplication from a limited donor sources, while those which maintain phenotype will :e of use in controlled pharmacological testing.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |